なに何naniしろshiro
1.
A phrase used to emphasize that regardless of other circumstances, the main point or conclusion remains the same.
2.
An expression indicating that other matters are set aside, highlighting the importance of a particular issue, often conveying a sense of urgency or necessity to act in light of the situation.
3.
A way to assert that despite various considerations, one must acknowledge a definitive outcome or priority that should be focused on.
Example:
何しろ小さい店なので、彼は会計係から倉庫係まで多くの仕事を一手にこなさなければならない。